During her introductory remarks for last night's New York premiere of her film Bachelorette, hosted by SVEDKA Vodka and The Peggy Siegal Company, writer-director Leslye Headland saw fit to do some reminiscing about her history with the venue: the Lower East Side's Landmark Sunshine Cinema.

"I did coke in that theater during a midnight showing of Fear and Loathing, and then threw up all over the bathroom!" Headland recalled cheerfully. "Colleeeeege."

It stunned the audience, then cracked them up—these introductory speeches usually just consist of a list of names to thank, and jaded premiere-goers are accustomed to tuning them out. But doing things by the book isn't Headland's style; and her speech was the perfect introduction to her raunchy, hilarious, and altogether unexpected film. In it, three friends from high school (Isla Fisher, Kirsten Dunst, and Lizzy Caplan) are forced to come to terms with the people they once were and the people they've become when a fourth high-school pal (Rebel Wilson)—the chubby one, the butt of the jokes—gets married.

For her part, and despite her résumé, Caplan—who looked stunning in a blue leather Halston dress—managed to bypass the mean-girl stage in high school. " I was lucky enough to have an older sister who was ridiculously cool, so I just copied everything she did. She learned all those lessons a few years before I did," Caplan said. " So I feel like I ended up being a pretty decent human being by the time I hit high school, since I saw her doing all this terrible shit to people."

Arden Myrin, who has a small but very memorable turn in the film as the owner of a bridal boutique, didn't have it so easy. "I looked like I was Ron Howard when I was 16," she laughed. "For me, it was more just like, 'Hang in there!'"

As for Isla Fisher, her advice to her teenaged self was simple: "It's all going to work out. Take the tissues out of your bra." —Alexandria Symonds